Valproate, the Urea Cycle, and Hyperammonemia
This is a technical and "must read" article about how valproate may interfere with the urea cycle and lead to hyperammonemia. If the risk here is recognized, it may be possible to use vitamin supplements along with the medication to avoid the danger and enable the drug to work effectively.
Seizures are one of the symptoms of hyperammonemia.
Link to Article:
Labels: B6 epilepsy, hyperammonemia, psychiatric drugs hyperammonemia, seizures